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Jump to the Navigation Menu Login to My AlzForum Jump to the Search form NEWS New ACE Variant Speeds Neurodegeneration in Alzheimer’s Mice Add To My AlzForum 2 comments 02 Oct 2020 The R1279Q variant of angiotensin-converting enzyme associates with AD and causes neurodegeneration in mice. In a model of amyloidosis, it accelerates decline. Virtual Meetings Try Out Different Formats Add To My AlzForum 02 Oct 2020 A recent genetics symposium drew positive reviews for its approach of following up prerecorded, on-demand talks with a live Q&A session. VCP Coding Mutation Causes a Tauopathy With Vacuoles Add To My AlzForum 5 comments 02 Oct 2020 Carriers of a rare hypomorphic gene variant develop a frontotemporal dementia that features Alzheimer’s-like neurofibrillary tangles. FDA Advisors Will Take up Aducanumab on November 6 Add To My AlzForum 02 Oct 2020 The day-long advisory committee meeting will be broadcast live online. Prerecorded presentations are to be available November 4; the public can submit comments. Of Four Aβ Antibodies, Only Aducanumab Stems Tide of Toxic Oligomers Add To My AlzForum 5 comments 28 Sep 2020 While one anti-Aβ antibody thwarts initial seeding of fibrils, and others keep fibrils from lengthening, aducanumab prevents oligomers forming on their surface. In vitro, that is. Introducing the Coarse-Grained Plaque—A New Type of Amyloid Add To My AlzForum 1 comment 26 Sep 2020 Comprising mostly Aβ40, these large plaques are shot through with strange tubular structures and BBB markers. They are common in early onset AD. Nixing TMEM106b Fans the Flames of Progranulin Deficiency Add To My AlzForum 2 comments 25 Sep 2020 Three studies agree that TMEM106b/progranulin double knockouts develop more extreme lysosomal dysfunction, inflammation, and motor deficits than PGRN KOs. Protective AD Variant Pinpoints Sweet Spot for Microglial Activation Add To My AlzForum 3 comments 24 Sep 2020 Phospholipase C-γ2 acts downstream of TREM2 to rev up beneficial inflammation, phagocytosis, and cell survival. View All News Virtual Exhibit Hall Alzforum encourages users to visit the Virtual Exhibit Hall , where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Abcam, BrainXell, and the Jackson Laboratory. SPOTLIGHT Antibodies Throw Wrench into Aβ Assembly Line Sure, all anti-Aβ antibodies hobble some aspect of the peptide’s aggregation, but a head-to-head comparison of four investigational monoclonals turned up dramatically different mechanisms. While solanezumab stopped new fibrils from forming in the first place, gantenerumab and bapineuzumab kept fibrils from getting longer. Aducanumab sabotaged secondary nucleation, the process whereby fibrils catalyze the formation of new oligomers, the most toxic of Aβ species. Behold, the Coarse-Grained Plaque Pathologists have newly characterized a beefy type of plaque that seems distinct from cotton-wool and dense-core plaques. Coarse-grained plaques, as they are called, can grow to be a tenth of a millimeter across. They associate with blood vessels and are more common in early onset AD and in people who carry two copies of ApoE4. They could help researchers understand the origin of amyloid plaques. Alzforum reaches 5,000 followers on Twitter. A big thanks to all of you who find, read, and share our content for helping spread the word about Alzforum. If you aren’t already, you can follow us on Twitter , LinkedIn , or Facebook to get content updates in your social media feed. Check our Social Media page to see what we post on each platform and chose what is right for you. Join The Conversation Latest Comments Giulio Pasinetti on New ACE Variant Speeds Neurodegeneration in Alzheimer’s Mice 02 Oct 2020 Edo Richard on New ACE Variant Speeds Neurodegeneration in Alzheimer’s Mice 02 Oct 2020 Manuela Neumann on VCP Coding Mutation Causes a Tauopathy With Vacuoles 02 Oct 2020 James Shorter on VCP Coding Mutation Causes a Tauopathy With Vacuoles 02 Oct 2020 Rita Guerreiro on VCP Coding Mutation Causes a Tauopathy With Vacuoles 02 Oct 2020 Laura Blair on VCP Coding Mutation Causes a Tauopathy With Vacuoles 02 Oct 2020 Marc Diamond and Sushobhna Batra on VCP Coding Mutation Causes a Tauopathy With Vacuoles 02 Oct 2020 Valentina Escott-Price, Julie Williams and Bart De Strooper on Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture. 02 Oct 2020 Neil Cashman on Of Four Aβ Antibodies, Only Aducanumab Stems Tide of Toxic Oligomers 01 Oct 2020 Per-Ola Freskgård, Christer Möller and Lars Lannfelt on Of Four Aβ Antibodies, Only Aducanumab Stems Tide of Toxic Oligomers 30 Sep 2020 Elsa Lauwers, Giovanna Lalli and Bart De Strooper on Could Contaminated Scalpels Seed Amyloidosis? 30 Sep 2020 Markus Damme on Nixing TMEM106b Fans the Flames of Progranulin Deficiency 30 Sep 2020 Martin Page on Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies. 30 Sep 2020 José Luna-Muñoz on Peter Davies, Beloved Giant of Alzheimer’s Disease Research, Dies at 72 30 Sep 2020 Heinz Hillen on Of Four Aβ Antibodies, Only Aducanumab Stems Tide of Toxic Oligomers 29 Sep 2020 Rudy Tanzi on Of Four Aβ Antibodies, Only Aducanumab Stems Tide of Toxic Oligomers 29 Sep 2020 Colin Masters and Steven Collins on Could Contaminated Scalpels Seed Amyloidosis? 29 Sep 2020 Luke Miles on Of Four Aβ Antibodies, Only Aducanumab Stems Tide of Toxic Oligomers 28 Sep 2020 Stephen Strittmatter on Nixing TMEM106b Fans the Flames of Progranulin Deficiency 28 Sep 2020 Jesse Cedarbaum on Cancer Treatment Takes Aim at Tauopathy 27 Sep 2020 Dietmar Thal on Introducing the Coarse-Grained Plaque—A New Type of Amyloid 26 Sep 2020 View All Comments Professional Resources New in last 7 days Grants New Items: 1 Total Items: 128 Jobs New Items: 4 Total Items: 67 Conference Calendar New Items: 1 Total Items: 80 Member Directory Enter your keywords LOGIN HOME About Us Newsletter NEWS All News Conference Coverage WEBINARS All Webinars Databases AlzBiomarker AlzPedia AlzRisk Antibodies Brain Banks Genetics AlzGene HEX Mutations Protocols Research Models Therapeutics PAPERS All Papers Papers of the Week Milestone Alzforum Recommends PROFESSIONAL RESOURCES Conference Calendar Grants Jobs Member Directory Virtual Exhibit Hall ABOUT AD Research Timeline Clinical Trial Registries Early Onset Familial Films About Alzheimer's MOOCs MY ALZFORUM My AlzForum Home View Library View Notifications Set Notifications Edit Profile Back to the Top Terms of Use How to Cite Privacy Policy Site Map Contact Us Facebook Twitter Linked In RSS Copyright © 1996–2020 FBRI LLC. 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